You can apply Awesome Assertions to your generic dictionaries as well. Of course you can assert any dictionary to be null or not null, and empty or not empty. Like this:

Dictionary<int, string> dictionary;
dictionary.Should().BeNull();

dictionary = new Dictionary<int, string>();
dictionary.Should().NotBeNull();
dictionary.Should().BeEmpty();
dictionary.Add(1, "first element");
dictionary.Should().NotBeEmpty();

You can also assert the equality of the entire dictionary, where the equality of the keys and values will be validated using their Equals implementation. Like this:

var dictionary1 = new Dictionary<int, string>
{
    { 1, "One" },
    { 2, "Two" }
};

var dictionary2 = new Dictionary<int, string>
{
    { 1, "One" },
    { 2, "Two" }
};

var dictionary3 = new Dictionary<int, string>
{
    { 3, "Three" },
};

dictionary1.Should().Equal(dictionary2);
dictionary1.Should().NotEqual(dictionary3);

Or you can assert that the dictionary contains a certain key or value:

dictionary.Should().ContainKey(1);
dictionary.Should().ContainKeys(1, 2);
dictionary.Should().NotContainKey(9);
dictionary.Should().NotContainKeys(9, 10);
dictionary.Should().ContainValue("One");
dictionary.Should().ContainValues("One", "Two");
dictionary.Should().NotContainValue("Nine");
dictionary.Should().NotContainValues("Nine", "Ten");

You can also assert that the dictionary has a certain number of items:

dictionary.Should().HaveCount(2);
dictionary.Should().NotHaveCount(3);

dictionary1.Should().HaveSameCount(dictionary2);
dictionary1.Should().NotHaveSameCount(dictionary3);

dictionary1.Should().HaveSameCount(dictionary2.Keys);
dictionary1.Should().NotHaveSameCount(dictionary3.Keys);

And finally you can assert that the dictionary contains a specific key/value pair or not:

var item1 = new KeyValuePair<int, string>(1, "One");
var item2 = new KeyValuePair<int, string>(2, "Two");

dictionary.Should().Contain(item1);
dictionary.Should().Contain(item1, item2);
dictionary.Should().Contain(2, "Two");
dictionary.Should().NotContain(item1);
dictionary.Should().NotContain(item1, item2);
dictionary.Should().NotContain(9, "Nine");

Chaining additional assertions is supported as well.

dictionary.Should().ContainValue(myClass)
  .Which.SomeProperty.Should().BeGreaterThan(0);